Peripartum effects of synthetic oxytocin: the good, the bad, and the unknown

M Rashidi, E Maier, S Dekel, M Sütterlin… - Neuroscience & …, 2022 - Elsevier
The first clinical applications of oxytocin (OT) were in obstetrics as a hormone to start and
speed up labor and to control postpartum hemorrhage. Discoveries in the 1960s and 1970s …

The modulation of emotional and social behaviors by oxytocin signaling in limbic network

R Triana-Del Rio, S Ranade, J Guardado… - Frontiers in Molecular …, 2022 - frontiersin.org
Neuropeptides can exert volume modulation in neuronal networks, which account for a well-
calibrated and fine-tuned regulation that depends on the sensory and behavioral contexts …

Hypermethylation of the oxytocin receptor gene (OXTR) in obsessive-compulsive disorder: Further evidence for a biomarker of disease and treatment response

K Bey, R Campos-Martin, J Klawohn, B Reuter… - Epigenetics, 2022 - Taylor & Francis
Obsessive-compulsive disorder (OCD) has recently been linked to increased methylation
levels in the oxytocin receptor (OXTR) gene, and OXTR hypermethylation has predicted a …

Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2

LC Da Prato, U Zayan, D Abdallah, V Point… - …, 2022 - nature.com
Atypical responses to sensory stimuli are considered as a core aspect and early life marker
of autism spectrum disorders (ASD). Although recent findings performed in mouse ASD …

Intranasal oxytocin for negative symptoms of schizophrenia: systematic review, meta-analysis, and dose-response meta-analysis of randomized controlled trials

M Sabe, N Zhao, A Crippa, GP Strauss… - International Journal of …, 2021 - academic.oup.com
Background Negative symptoms are a core aspect of psychopathology in schizophrenia.
Currently available pharmacological agents have proven minimally efficacious for …

Personality and social relationships: What do we know and where do we go

MD Back, S Branje, PW Eastwick… - Personality …, 2023 - journals.sagepub.com
Personality and social relationships influence each other in multiple and consequential
ways. To understand how people differ from each other in their personality and social …

Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner

CL Ford, AA McDonough, K Horie, LJ Young - Neuropharmacology, 2024 - Elsevier
Social deficits are debilitating features of many psychiatric disorders, including autism. While
time-intensive behavioral therapy is moderately effective, there are no pharmacological …

Role of oxytocin in different neuropsychiatric, neurodegenerative, and neurodevelopmental disorders

AA Ghazy, OA Soliman, AI Elbahnasi, AY Alawy… - Reviews of physiology …, 2022 - Springer
Oxytocin has recently gained significant attention because of its role in the pathophysiology
and management of dominant neuropsychiatric disorders. Oxytocin, a peptide hormone …

[HTML][HTML] The effects of oxytocin administration on social and routinized behaviors in autism: A preregistered systematic review and meta-analysis

K Audunsdottir, AM Sartorius, H Kang, B Glaser… - …, 2024 - Elsevier
Oxytocin administration has demonstrated considerable promise for providing individualized
support for autistic people. However, studies evaluating the effects of oxytocin administration …

[HTML][HTML] Towards better hypothesis tests in oxytocin research: Evaluating the validity of auxiliary assumptions

DS Quintana - Psychoneuroendocrinology, 2022 - Elsevier
Various factors have been attributed to the inconsistent reproducibility of human oxytocin
research in the cognitive and behavioral sciences. These factors include small sample sizes …