Relationship between P-glycoprotein and second-generation antipsychotics
The membrane transport protein P-glycoprotein (P-gp) is an interesting candidate for
individual differences in response to antipsychotics. To present an overview of the current …
individual differences in response to antipsychotics. To present an overview of the current …
Personalized medicine: is it a pharmacogenetic mirage?
RR Shah, DR Shah - British journal of clinical pharmacology, 2012 - Wiley Online Library
The notion of personalized medicine has developed from the application of the discipline of
pharmacogenetics to clinical medicine. Although the clinical relevance of genetically …
pharmacogenetics to clinical medicine. Although the clinical relevance of genetically …
[HTML][HTML] ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression
The ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1
(ABCB1)(P-glycoprotein) transporter is a key component of the blood–brain barrier. Many …
(ABCB1)(P-glycoprotein) transporter is a key component of the blood–brain barrier. Many …
IL-1β biological treatment of familial Mediterranean fever
A Soriano, E Verecchia, A Afeltra, R Landolfi… - Clinical Reviews in …, 2013 - Springer
Familial Mediterranean fever (FMF) is a recessive, autosomal, auto-inflammatory disorder
characterised by brief, recurring, self-limited episodes of fever and serositis resulting in …
characterised by brief, recurring, self-limited episodes of fever and serositis resulting in …
Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment
K Darney, L Turco, FM Buratti, E Di Consiglio… - Food and chemical …, 2020 - Elsevier
Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …
Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil …
N Muralidharan, PT Antony, VK Jain… - European journal of …, 2015 - Springer
Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily
targeting the synovial joints causing joint damage and significant functional impairment …
targeting the synovial joints causing joint damage and significant functional impairment …
High prevalence of CYP2C19* 2 allele in Roma samples: study on Roma and Hungarian population samples with review of the literature
The purpose of our study was to characterise the CYP2C19* 2 and CYP2C19* 3 alleles in
healthy Roma and Hungarian populations. DNA of 500 Roma and 370 Hungarian subjects …
healthy Roma and Hungarian populations. DNA of 500 Roma and 370 Hungarian subjects …
[HTML][HTML] Marked differences in frequencies of statin therapy relevant SLCO1B1 variants and haplotypes between Roma and Hungarian populations
Background SLCO1B1 polymorphisms are relevant in statin pharmacokinetics. Aim of this
study was to investigate the genetic variability and haplotype profile of SLCO1B1 …
study was to investigate the genetic variability and haplotype profile of SLCO1B1 …
[HTML][HTML] Characterization of ADME genes variation in Roma and 20 populations worldwide
The products of the polymorphic ADME genes are involved in Absorption, Distribution,
Metabolism, and Excretion of drugs. The pharmacogenetic data have been studied …
Metabolism, and Excretion of drugs. The pharmacogenetic data have been studied …
Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients
The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette
transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in …
transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in …