Most reactive oxygen species (ROS) are generated in cells by the mitochondrial respiratory
chain. Mitochondrial ROS production is modulated largely by the rate of electron flow …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

TLR agonists initiate a rapid activation program in dendritic cells (DCs) that requires support
from metabolic and bioenergetic resources. We found previously that TLR signaling …

While cellular responses to low oxygen (O 2) or hypoxia have been studied extensively, the
precise identity of mammalian cellular O 2 sensors remains controversial. Using murine …

Abstract Peroxynitrite (ONOO−), the reaction product derived from nitric oxide (NO) and
superoxide (O2−•), is a potent oxidizing and nitrating agent that modulates complex …

Radiotherapy (RT) is one of the most effective and frequent clinical cancer treatments.
Nevertheless, RT can cause damage to normal tissues around tumors under high-dose …

Oxygen depravation in mammals leads to the transcriptional induction of a host of target
genes to metabolically adapt to this deficiency, including erythropoietin and vascular …

In recent years, the altitude acclimatization responses elicited by short-term intermittent
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …

Objective To examine tissue hypoxia in the retina and optic nerve head of
glaucomatouseyes by the assessment of a transcription factor, hypoxia-inducible factor1α …

Nitric oxide (NO) has been reported both to promote and to inhibit the activity of the
transcription factor hypoxia-inducible factor-1 (HIF-1). In order to avoid the pitfalls associated …