Hypoxia exists in solid tumor tissues due to abnormal vasculature, vascular insufficiency,
treatment or malignancy related anemia, and low intratumor blood flow. Hypoxic status in …

In humans both the levels and activity of the α-subunit of the hypoxia-inducible transcription
factor (HIF-α) are regulated by its post-translation hydroxylation as catalyzed by iron-and 2 …

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by
mediating a wide range of cellular and systemic adaptive physiological responses to …

Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …

The heterodimeric transcription factor HIF (hypoxia-inducible factor), consisting of a labile α-
subunit and a stable β-subunit, is a master regulator of genes involved in acute or chronic …

Hypoxia is one of the most frequently encountered stresses in health and disease. The
duration, frequency, and severity of hypoxic episodes are critical factors determining …

Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible
factor (HIF)-1α, a primary constituent associated with hypoxic angiogenesis and a regulator …

Reactive oxygen species (ROS) have long been considered only as cyto-and genotoxic.
However, there is now compelling evidence that ROS also act as second messengers in …

Nitric oxide (NO) is a lipophilic, highly diffusible and short-lived physiological messenger
which regulates a variety of important physiological responses including vasodilation …

The transcription factor complex hypoxia-inducible factor 1 (HIF-1) plays a crucial role in
cellular adaptation to low oxygen availability. O 2-dependent HIF prolyl hydroxylases …