Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in
250,000 individuals. The disease is caused by a lack of superoxide production by the …

Infection of humans with M ycobacterium tuberculosis remains frequent and may still lead to
death. After primary infection, the immune system is often able to control M. tuberculosis …

Background: Chronic granulomatous disease (CGD) is a rare disorder of phagocytic
oxidative bursts leading to recurrent pyogenic infections. Affected individuals are most prone …

A few known primary immunodeficiencies confer predisposition to clinical disease caused
by weakly virulent mycobacteria, such as BCG vaccines (regional disease, known as BCG …

Females have a longer lifespan and better general health than males. Considerable number
of studies also demonstrated that, after trauma and sepsis, females present better outcomes …

Females as compared with males display better general health status, longevity, and
improved clinical course after injury and infection. It is generally believed that the female …

Background. Chronic granulomatous disease (CGD) is a rare inherited disease of the
phagocyte NADPH oxidase system that causes defective production of toxic oxygen …

The most important subjects reviewed in this chapter include new advances in development
of gene therapy for chronic granulomatous disease and leukocyte adhesion deficiency-I; …

Background Reactive oxygen species (ROS) generated by NADPH oxidase has a pivotal
role in the nonspecific innate immune response to invading microorganisms including M …

Background Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI),
characterised by recurrent bacterial and fungal infections. It is inherited either in an X-linked …