Anti-HIV drug discovery and development: current innovations and future trends: miniperspective
P Zhan, C Pannecouque, E De Clercq… - Journal of medicinal …, 2016 - ACS Publications
The early effectiveness of combinatorial antiretroviral therapy (cART) in the treatment of HIV
infection has been compromised to some extent by rapid development of multidrug-resistant …
infection has been compromised to some extent by rapid development of multidrug-resistant …
[HTML][HTML] Medicinal plants used in the treatment of human immunodeficiency virus
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected
around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There …
around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There …
[HTML][HTML] CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs
Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent
HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has been …
HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has been …
[HTML][HTML] Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation
Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …
Discovery and development of anti-HIV therapeutic agents: progress towards improved HIV medication
The history of the human immunodeficiency virus (HIV)/AIDS therapy, which spans over 30
years, is one of the most dramatic stories of science and medicine leading to the treatment of …
years, is one of the most dramatic stories of science and medicine leading to the treatment of …
[HTML][HTML] Regulation of chemokines and cytokines by histone deacetylases and an update on histone decetylase inhibitors in human diseases
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …
[HTML][HTML] Advances in developing CAR T-cell therapy for HIV cure
J Qi, C Ding, X Jiang, Y Gao - Frontiers in Immunology, 2020 - frontiersin.org
Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an
epidemic disease that has killed millions of people in the last several decades. Although …
epidemic disease that has killed millions of people in the last several decades. Although …
HDAC 6 regulates cellular viral RNA sensing by deacetylation of RIG‐I
RIG‐I is a key cytosolic sensor that detects RNA viruses through its C‐terminal region and
activates the production of antiviral interferons (IFN s) and proinflammatory cytokines. While …
activates the production of antiviral interferons (IFN s) and proinflammatory cytokines. While …
[HTML][HTML] What do we measure when we measure cell-associated HIV RNA
AO Pasternak, B Berkhout - Retrovirology, 2018 - Springer
Abstract Cell-associated (CA) HIV RNA has received much attention in recent years as a
surrogate measure of the efficiency of HIV latency reversion and because it may provide an …
surrogate measure of the efficiency of HIV latency reversion and because it may provide an …
Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS
Objective: There is an urgent need for the development of HIV-1 genome eradication
strategies that lead to a permanent cure for HIV-1/AIDS. We previously reported that four …
strategies that lead to a permanent cure for HIV-1/AIDS. We previously reported that four …