Animal models of asthma
Animal models of asthma are a tool that allows studies to be conducted in the setting of an
intact immune and respiratory system. These models have highlighted the importance of T …
intact immune and respiratory system. These models have highlighted the importance of T …
Animal models of asthma: value, limitations and opportunities for alternative approaches
AM Holmes, R Solari, ST Holgate - Drug discovery today, 2011 - Elsevier
Asthma remains an area of considerable unmet medical need. Few new drugs have made it
to the clinic during the past 50 years, with many that perform well in preclinical animal …
to the clinic during the past 50 years, with many that perform well in preclinical animal …
Altered lung function relates to inflammation in an acute LPS mouse model
HF Håkansson, A Smailagic, C Brunmark… - Pulmonary …, 2012 - Elsevier
Preclinical in vivo models of lipopolysaccharide (LPS)-induced acute lung injury are
commonly used to recapitulate pathophysiological features of chronic obstructive pulmonary …
commonly used to recapitulate pathophysiological features of chronic obstructive pulmonary …
Ovalbumin‐sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation
GR Zosky, AN Larcombe, OJ White… - Clinical & …, 2008 - Wiley Online Library
Background Asthma is a chronic inflammatory disease that is characterized clinically by
airway hyperresponsiveness (AHR) to bronchoconstricting agents. The physiological …
airway hyperresponsiveness (AHR) to bronchoconstricting agents. The physiological …
Measurement of airway function using invasive and non-invasive methods in mild and severe models for allergic airway inflammation in mice
KAT Verheijden, PAJ Henricks, FA Redegeld… - Frontiers in …, 2014 - frontiersin.org
In this study a direct comparison was made between non-invasive and non-ventilated
unrestrained whole body plethysmography (Penh)(conscious animals) and the invasive …
unrestrained whole body plethysmography (Penh)(conscious animals) and the invasive …
The role of murine models in the study of the respiratory tract immune response induced by particulate matter
DM Gomez, JH Tabares-Guevara… - Air Quality, Atmosphere …, 2023 - Springer
Environmental air pollution is a global problem. Among the main types of air pollutants that
harm human health are ozone, particulate matter (PM), nitrogen, carbon dioxide, sulfur …
harm human health are ozone, particulate matter (PM), nitrogen, carbon dioxide, sulfur …
The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice
H Zhu, C Perkins, MK Mingler, FD Finkelman… - Peptides, 2011 - Elsevier
Genome-wide screening and positional cloning have linked neuropeptide S receptor 1
(NPSR1) with asthma and airway hyperresponsiveness. However, the mechanism by which …
(NPSR1) with asthma and airway hyperresponsiveness. However, the mechanism by which …
Methacholine responsiveness in mice from 2 to 8 wk of age
EM Bozanich, TZ Jánosi, RA Collins… - Journal of applied …, 2007 - journals.physiology.org
Many chronic human lung diseases have their origin in early childhood, yet most murine
models used to study them utilize adult mice. An important component of the asthma …
models used to study them utilize adult mice. An important component of the asthma …
[图书][B] In Vivo Models of Inflammation: Volume 1
CS Stevenson, LA Marshall, DW Morgan - 2006 - books.google.com
Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the
pharmaceutical industry and academia with a description of the state of the art animal model …
pharmaceutical industry and academia with a description of the state of the art animal model …