Learning and memory are associated with the formation and modification of neuronal
assemblies: populations of neurons that encode what has been learned and mediate …

Previous studies have revealed the existence of hippocampal “time cells,” principal neurons
in CA1 that fire at specific moments in temporally organized experiences. However, in all …

Sleep is composed of an alternating sequence of REM and non-REM episodes, but their
respective roles are not known. We found that the overall firing rates of hippocampal CA1 …

Most studies on memory consolidation consider the new information as if it were imposed on
a tabula rasa, but considerable evidence indicates that new memories must be interleaved …

Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …

Reward motivation is known to modulate memory encoding, and this effect depends on
interactions between the substantia nigra/ventral tegmental area complex (SN/VTA) and the …

Artificial autonomous agents and robots interacting in complex environments are required to
continually acquire and fine-tune knowledge over sustained periods of time. The ability to …

Consolidation of memory is believed to involve offline replay of neural activity. While amply
demonstrated in rodents, evidence for replay in humans, particularly regarding motor …

Sequences of spiking activity have been heavily implicated as potential substrates of
memory formation and retrieval across many species. A parallel line of recent evidence also …

The encoding and storage of experience by the hippocampus is essential for the formation
of episodic memories and the transformation of individual experiences into semantic …