Pyrrolizidine alkaloids in the food chain: Is horizontal transfer of natural products of relevance?

MS Chmit, G Horn, A Dübecke, T Beuerle - Foods, 2021 - mdpi.com
Recent studies have raised the question whether there is a potential threat by a horizontal
transfer of toxic plant constituents such as pyrrolizidine alkaloids (PAs) between donor-PA …

Chemical fingerprinting identifies Echium vulgare, Eupatorium cannabinum and Senecio spp. as plant species mainly responsible for pyrrolizidine alkaloids in bee …

C Kast, V Kilchenmann, H Reinhard… - Food Additives & …, 2018 - Taylor & Francis
Various studies have shown that bee-collected pollen sold as nutritional supplements may
contain toxic pyrrolizidine alkaloids (PAs) and, thus, pose a potential health risk for …

Risk assessment of contaminants in food and feed

J Alexander, D Benford, A Boobis, M Eskola… - Efsa …, 2012 - Wiley Online Library
Abstract The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) carries out
risk assessment on contaminants in food and feed. The presence of hazardous chemical …

Pyrrolizidine Alkaloids in Food on the Italian Market

M Peloso, G Minkoumba Sonfack, S Paduano… - Molecules, 2023 - mdpi.com
Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by over 6000 plant
species worldwide. PAs enter the food chain through accidental co-harvesting of PA …

Heliotropium europaeum Poisoning in Cattle and Analysis of Its Pyrrolizidine Alkaloid Profile

JA Shimshoni, PPJ Mulder, A Bouznach… - Journal of agricultural …, 2015 - ACS Publications
Pyrrolizidine alkaloids (PAs) are carcinogenic and genotoxic phytochemicals found
exclusively in angiosperms. The ingestion of PA-containing plants often results in acute and …

Worldwide occurrence and investigations of contamination of herbal medicines by tropane alkaloids

TYK Chan - Toxins, 2017 - mdpi.com
Tropane alkaloids occur mainly in Solanaceae plants. In the present review, the main
objective is to describe the worldwide occurrence and investigations of anticholinergic …

Spread of Jacobaea vulgaris and Occurrence of Pyrrolizidine Alkaloids in Regionally Produced Honeys from Northern Germany: Inter- and Intra-Site Variations and …

C Gottschalk, F Kaltner, M Zimmermann, R Korten… - Toxins, 2020 - mdpi.com
Pyrrolizidine alkaloids (PA) and PA N-oxides (PANO) are secondary plant metabolites
exhibiting genotoxic and carcinogenic properties. Apart from the roots and leaves, PA/PANO …

Simultaneous determination of pesticides, mycotoxins, tropane alkaloids, growth regulators, and pyrrolizidine alkaloids in oats and whole wheat grains after online …

M Urban, S Hann, H Rost - Journal of Environmental Science and …, 2019 - Taylor & Francis
In this study, a two-dimensional liquid chromatography tandem mass spectrometry method
was developed and validated for the determination of pesticide residues and contaminants …

High abundance of pyrrolizidine alkaloids in bee pollen collected in July 2019 from Southern Germany

C Friedle, T Kapp, K Wallner, R Alkattea… - Environmental Monitoring …, 2022 - Springer
Pyrrolizidine alkaloids (PA) are secondary plant defense compounds and known pre-toxins
when containing a 1, 2-double bond. They are commonly produced by various plants and …

The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey‐derived pyrrolizidine alkaloids, lycopsamine and intermedine …

AW Brown, BL Stegelmeier… - Journal of Applied …, 2016 - Wiley Online Library
Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine
alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic …