[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
[HTML][HTML] Patient-derived tumor organoids for prediction of cancer treatment response
PW Nagle, JTM Plukker, CT Muijs, P van Luijk… - Seminars in cancer …, 2018 - Elsevier
Cancer treatment, in particular radiotherapy and chemotherapy, is often hindered by an
inherent resistance of cancer cells. Cancer stem cells in particular have previously been …
inherent resistance of cancer cells. Cancer stem cells in particular have previously been …
[HTML][HTML] Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer
KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …
Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate
intracellular signalling pathways that promote cancer cell survival and tumour growth …
intracellular signalling pathways that promote cancer cell survival and tumour growth …
Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors
Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC)
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …
MYC instructs and maintains pancreatic adenocarcinoma phenotype
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment
C Kim-Fuchs, CP Le, MA Pimentel… - Brain, behavior, and …, 2014 - Elsevier
Pancreatic cancer cells intimately interact with a complex microenvironment that influences
pancreatic cancer progression. The pancreas is innervated by fibers of the sympathetic …
pancreatic cancer progression. The pancreas is innervated by fibers of the sympathetic …
[HTML][HTML] CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer
J Franco, AK Witkiewicz, ES Knudsen - Oncotarget, 2014 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, in part, due to the therapy-
recalcitrant nature of the disease. Loss of the CDK4/6 inhibitor CDKN2A is a signature …
recalcitrant nature of the disease. Loss of the CDK4/6 inhibitor CDKN2A is a signature …
A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
B Philip, CL Roland, J Daniluk, Y Liu, D Chatterjee… - Gastroenterology, 2013 - Elsevier
Background & Aims Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC),
but it is not clear how obesity contributes to pancreatic carcinogenesis. The oncogenic form …
but it is not clear how obesity contributes to pancreatic carcinogenesis. The oncogenic form …
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
R Pothuraju, S Rachagani, WM Junker… - Journal of Experimental …, 2018 - Springer
Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …