New selective ligands of human cloned melatonin MT1 and MT2 receptors
V Audinot, F Mailliet, C Lahaye-Brasseur… - Naunyn-Schmiedeberg's …, 2003 - Springer
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors …
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors …
Comprehensive survey of combinatorial library synthesis: 2000
RE Dolle - Journal of combinatorial chemistry, 2001 - ACS Publications
Publications from both academic and industry on the synthesis and application of chemical
libraries continued at a rapid pace in 2000. The total number of libraries cited was 284 …
libraries continued at a rapid pace in 2000. The total number of libraries cited was 284 …
N-(Substituted-anilinoethyl)amides: Design, Synthesis, and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands
A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)
amido scaffold, along with preliminary structure–activity relationships (SARs), is presented …
amido scaffold, along with preliminary structure–activity relationships (SARs), is presented …
Dynamic Kinetic Resolution of 2‐Phenylpropanal Derivatives to Yield β‐Chiral Primary Amines via Bioamination
CS Fuchs, M Hollauf, M Meissner… - Advanced Synthesis …, 2014 - Wiley Online Library
The amination of racemic α‐chiral aldehydes, 2‐phenylpropanal derivatives, was
investigated employing ω‐transaminases. By medium and substrate engineering the optical …
investigated employing ω‐transaminases. By medium and substrate engineering the optical …
Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors
C Jellimann, M Mathé-Allainmat… - Journal of medicinal …, 2000 - ACS Publications
Conformationally restricted phenalene and acenaphthene derivatives 5 were synthesized
from phenalen-1-one and acenaphthen-1-one derivatives using the Horner− Emmons …
from phenalen-1-one and acenaphthen-1-one derivatives using the Horner− Emmons …
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors
A Carocci, A Catalano, A Lovece, G Lentini… - Bioorganic & medicinal …, 2010 - Elsevier
A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic
ligands. Modulation of affinity of the newly synthesized compound by applying SARs around …
ligands. Modulation of affinity of the newly synthesized compound by applying SARs around …
Synthesis of substituted N-[3-(3-methoxyphenyl) propyl] amides as highly potent MT2-selective melatonin ligands
Y Hu, MKC Ho, KH Chan, DC New, YH Wong - Bioorganic & Medicinal …, 2010 - Elsevier
A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …
Design and Synthesis of N-(3,3-Diphenylpropenyl)alkanamides as a Novel Class of High-Affinity MT2-Selective Melatonin Receptor Ligands
A novel series of melatonin receptor ligands was discovered by opening the cyclic scaffolds
of known classes of high affinity melatonin receptor antagonists, while retaining the …
of known classes of high affinity melatonin receptor antagonists, while retaining the …
Synthesis of new arylalkoxy amido derivatives as melatoninergic ligands
C Pégurier, L Morellato, E Chahed, J Andrieux… - Bioorganic & medicinal …, 2003 - Elsevier
Amido derivatives 10–18 of the corresponding oxyamines were synthesised as
melatoninergic ligands by the reaction of hydroxyphtalimide with the halogeno derivatives or …
melatoninergic ligands by the reaction of hydroxyphtalimide with the halogeno derivatives or …
Selenium-linking strategy for traceless solid-phase synthesis of acrylamides
SR Sheng, XC Wang, XL Liu, CS Song - Synthetic communications, 2003 - Taylor & Francis
Full article: Selenium-Linking Strategy for Traceless Solid-Phase Synthesis of Acrylamides Skip
to Main Content Taylor and Francis Online homepage Taylor and Francis Online homepage …
to Main Content Taylor and Francis Online homepage Taylor and Francis Online homepage …