Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex
plays a protective role in daily life by removing irritants, chronic itch remains a clinical …

The inflammatory response in the joint can induce an intense accumulation of leukocytes in
the tissue that frequently results in severe local damage and loss of function. Neutrophils are …

Objective This study aimed at evaluating the activity of curcumin in superoxide anion-
induced pain-like behavior and leukocyte recruitment in mice. Treatment Administration of …

Itch, the unpleasant sensation that elicits a desire to scratch, is mediated by specific
subtypes of cutaneous sensory neuron. Here, we identify a subpopulation of itch‐sensing …

Polycystic ovary syndrome (PCOS) is a common inflammatory disease with an uncertain
pathogenesis, although one consistent finding is increased neutrophil activity. It has been …

Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus.
However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the …

Over the last decades, a great array of molecular mediators have been identified as potential
targets for the treatment of chronic pain. Among these mediators, transient receptor potential …

The recently described 'gasomediator'hydrogen sulfide (H 2 S) has been involved in pain
mechanisms, but its effect on pruritus, a sensory modality that similarly to pain acts as a …

Psoriasis is a chronic inflammatory disease with unmet medical needs. To clarify potential
therapeutic targets, different animal models have been developed. In the current study …

Psoriasis is characterized by keratinocyte hyperproliferation, erythema, as well as a form of
pruritus, involving cutaneous discomfort. There is evidence from both clinical and murine …