T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …

Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …

Polychromatic flow cytometry results in complex, multivariate datasets. To date, tools for the
aggregate analysis of these datasets across multiple specimens grouped by different …

Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

Identification of T-cell subsets that are infected in vivo is essential to understanding the
pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been …

We present the results of a preliminary investigation of the efficacy of a therapeutic dendritic
cell (DC)-based vaccine for HIV-1. We immunized 18 chronically HIV-1-infected and …

Virus-specific CD4 T cells are endowed with multiple functions, such as cytokine production,
CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells) …

Abstract HIV-1-and cytomegalovirus (CMV)-specific CD4 T-cell-mediated antiviral immunity
was evaluated by assessing the frequency of interleukin 2 (IL-2)-and interferon γ (IFN-γ) …

CD4+ Th1 type immunity is implicated in resistance to global infectious diseases. To
improve the efficacy of T cell immunity induced by human immunodeficiency virus (HIV) …