Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

Heart failure with reduced ejection fraction (HFrEF) develops when cardiac output falls as a
result of cardiac injury. The most well-recognized of the compensatory homeostatic …

Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

The changes in left ventricular (LV) structure and geometry that evolve after myocardial
injury or overload usually involve chamber dilation and/or hypertrophy. Such architectural …

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …