Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Prostate cancer, the majority of which is adenocarcinoma, is the most common epithelial
cancer affecting a majority of elderly men in Western nations. Its manifestation, however …

Ever since Bishop and his co-workers discovered the c-myc gene in the late 1970s (Bishop
1982), voluminous literature has documented its central role in proliferation and malignant …

Purpose: The overexpression of c-myc associated with uncontrolled cell proliferation is a
frequent genetic event in androgen-refractory prostatic neoplasia. The purpose of this study …

Introduction Breast cancer is the leading cause of cancer death in women worldwide.
Elevated expression of c-Myc is a frequent genetic abnormality seen in this malignancy. For …

MYC is a transcription factor, which not only directly modulates multiple aspects of
transcription and co‐transcriptional processing (eg RNA‐Polymerase II initiation, elongation …

Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in
two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy) …

There is an inverse correlation between exposure to sunlight (the major source of vitamin D)
and the risk for prostate cancer, the most common noncutaneous cancer and second most …

Expression of the telomerase catalytic sub‐unit (htert) constitutes a key step in the
development of human cancer. Although htert regulation is still unclear, several studies …