Breast cancer is one of the well-known malignant tumors among women. In spite of attempts
to classifying breast cancer according to its histological and molecular properties, it is almost …

Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth,
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …

An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells
required to sustain a high proliferation rate. The DNL enzyme fatty acid synthase (FASN) is …

Metabolic reprogramming is recognized as a hallmark of cancer. Lipids are the essential
biomolecules required for membrane biosynthesis, energy storage, and cell signaling …

Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly
malignant, recurrent, drug‐resistant, and often diagnosed in the advanced stage. It is clear …

The processes of cell proliferation, cell death and differentiation involve an intricate array of
biochemical and morphological changes that require a finely tuned modulation of metabolic …

Lipid metabolism is a significant section of energy homeostasis, and it affects the
development of various cancers. Previous studies have revealed that berberine has strong …

Background Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement
of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic …