Serum starvation is one of the most frequently performed procedures in molecular biology
and there are literally thousands of research papers reporting its use. In fact, this method has …

L-amino acid oxidase (LAAO) from the Malayan pit viper induces both necrosis and
apoptosis in Jurkat cells. Cell death by necrosis is attributed to H 2 O 2 produced by …

Airway fibroblasts have become a critical addition to all facets of structural lung tissue
changes such as in human asthma and chronic obstructive pulmonary disease, but little is …

Aberrant levels of reactive oxygen species (ROS) rapidly generated from NADPH oxidase
(NOX) activation can be cytotoxic due to activating pro-apoptotic signals. However, ROS …

Fibroblast growth factor receptor (FGFR) activation by basic fibroblast growth factor (FGF-2)
serves to naturally repress the myofibroblast activation of valvular interstitial cells (VICs). Co …

Wnts are secreted glycoproteins that control diverse biological processes, such as
proliferation, differentiation, and apoptosis. We here found that Wnt5a inhibited apoptosis …

Androgens are essential for sexual development and reproduction. However, androgen
regulation in health and disease is poorly understood. We showed that human …

Tumors that acquire resistance against death stimuli constitute a severe problem in the
context of cancer therapy. To determine genetic alterations that favor the development of …

The effect of serum deprivation on proliferating cells is well known, in contrast its role on
primary cell cultures, at confluence, has not been deeply investigated. Therefore, in order to …

STAT3 has been implicated in mitochondrial function; however, the physiological relevance
of this action is not established. Here we studied the importance of STAT3 to the cellular …