Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Rho kinases (ROCKs) belong to the serine–threonine family, the inhibition of which affects
the function of many downstream substrates. As such, ROCK inhibitors have potential …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder
cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely …

Age is the most significant risk factor for atherosclerosis; however, the link between age and
atherosclerosis is poorly understood. During both aging and atherosclerosis progression …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

This study, using mouse embryonic fibroblast (MEF) cells derived from ROCK1−/− and
ROCK2−/− mice, is designed to dissect roles for ROCK1 and ROCK2 in regulating actin …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases,
were initially identified as downstream targets of the small GTP-binding protein Rho …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …