As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Understanding the plant immune system is crucial for using genetics to protect crops from
diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …