Dual Vascular Effects of Leptin via Endothelium: Hypothesis and Perspective Page 1
Corresponding author: Dr. Chiu-Yin Kwan, Department of Pharmacology, China Medical …

Voltage-gated ion channels are main players involved in fast synaptic events. However, only
slow intracellular mechanisms have so far been described for controlling their localization as …

Numerous brain regions are enriched with insulin and insulin receptors, and several lines of
evidence indicate that insulin is an important modulator of neuronal function. Indeed, recent …

The ketogenic diet is an effective treatment for medically intractable epilepsy and may have
antiepileptogenic, neuroprotective, and antitumor properties. While on a ketogenic diet, the …

The metabolic-related hormone, leptin has been suggested for clinical use as an
anticonvulsant based upon data generated from in vitro and in vivo non-human studies …

Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body
energy homeostasis and weight loss by activating leptin receptors in the hypothalamus …

The hormone leptin has widespread actions in the CNS. Indeed, leptin markedly influences
hippocampal excitatory synaptic transmission and synaptic plasticity. However, the effects of …

Abstract Voltage-gated potassium (K+) channel subfamily B member 1 (KCNB1, Kv2. 1) and
integrin-α5 form macromolecular complexes—named integrin-α5-KCNB1 complexes (IKCs) …

Purpose Febrile seizures (FS) are seizures that occur between the age of 6 and 60 months,
but its pathophysiology still is not fully understood. There is limited information about the …

In the present study, the neuroprotective effects of the adipokine leptin, and the molecular
mechanism involved, have been studied in rat and mice cortical neurons exposed to N …