The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls
the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2, 3, 7, 8 …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

The endothelium forms a vast network that dynamically regulates vascular barrier function,
coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely …

Pluripotent cells can be derived from fibroblasts by ectopic expression of defined
transcription factors. A fundamental unresolved question is whether terminally differentiated …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

Catabolic conditions like chronic kidney disease (CKD) cause loss of muscle mass by
unclear mechanisms. In muscle biopsies from CKD patients, we found activated Stat3 (p …

Rationale: Intercellular tight junctions are crucial for correct regulation of the endothelial
barrier. Their composition and integrity are affected in pathological contexts, such as …

The C/EBP family of proteins represents an important group of bZIP transcription factors that
are key to the regulation of essential functions such as cell cycle, hematopoiesis, skeletal …

Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at
axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously …