The disordered MAX N-terminus modulates DNA binding of the transcription factor MYC: MAX
The intrinsically disordered protein MYC belongs to the family of basic helix-loop-helix
leucine zipper (bHLH-LZ) transcription factors (TFs). In complex with its cognate binding …
leucine zipper (bHLH-LZ) transcription factors (TFs). In complex with its cognate binding …
KIT oncogene inhibition drives intratumoral macrophage M2 polarization
Tumor-associated macrophages (TAMs) are a major component of the cancer
microenvironment. Modulation of TAMs is under intense investigation because they are …
microenvironment. Modulation of TAMs is under intense investigation because they are …
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine …
N Su, MS Kilberg - Journal of Biological Chemistry, 2008 - ASBMB
C/EBP homology protein (CHOP), a stress-induced transcription factor, is involved in
transcriptional regulation, cell cycle, and apoptosis. The present studies identified CHOP as …
transcriptional regulation, cell cycle, and apoptosis. The present studies identified CHOP as …
The IL‐17 cytokine family
IL‐17A and its receptor are the founding members of a recently described cytokine family,
with unique sequences and functions in the immune system and elsewhere. Consisting of …
with unique sequences and functions in the immune system and elsewhere. Consisting of …
How does estrogen work on autophagy?
J Xiang, X Liu, J Ren, K Chen, H Wang, Y Miao, M Qi - Autophagy, 2019 - Taylor & Francis
Macroautophagy/autophagy is vital for intracellular quality control and homeostasis.
Therefore, careful regulation of autophagy is very important. In the past 10 years, a number …
Therefore, careful regulation of autophagy is very important. In the past 10 years, a number …
Biological roles of CCAAT/Enhancer-binding protein delta during inflammation
CY Ko, WC Chang, JM Wang - Journal of biomedical science, 2015 - Springer
CCAAT/enhancer-binding protein delta (CEBPD) belongs to the CCAAT/enhancer-binding
protein family, and these proteins function as transcription factors in many biological …
protein family, and these proteins function as transcription factors in many biological …
IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation
SM Park, H Cho, AM Thornton, TS Barlowe, T Chou… - Cell stem cell, 2019 - cell.com
Leukemias exhibit a dysregulated developmental program mediated through both genetic
and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells …
and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells …
Synthetic responses in airway smooth muscle
Human airway smooth muscle (ASM) has several properties and functions that contribute to
asthma pathogenesis, and increasing attention is being paid to its synthetic capabilities …
asthma pathogenesis, and increasing attention is being paid to its synthetic capabilities …
Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
C Forni, M Minuzzo, E Virdis, E Tamborini… - Molecular cancer …, 2009 - AACR
Differentiation is a complex set of events that can be blocked by rearrangements of
regulatory genes producing fusion proteins with altered properties. In the case of myxoid …
regulatory genes producing fusion proteins with altered properties. In the case of myxoid …
Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation: In memoriam Professor Niels Borregaard
Differentiation of multipotent stem cells into mature cells is fundamental for development and
homeostasis of mammalian tissues, and requires the coordinated induction of lineage …
homeostasis of mammalian tissues, and requires the coordinated induction of lineage …