Placental endocrine activity: adaptation and disruption of maternal glucose metabolism in pregnancy and the influence of fetal sex
C Stern, S Schwarz, G Moser, S Cvitic… - International journal of …, 2021 - mdpi.com
The placenta is an endocrine fetal organ, which secretes a plethora of steroid-and proteo-
hormones, metabolic proteins, growth factors, and cytokines in order to adapt maternal …
hormones, metabolic proteins, growth factors, and cytokines in order to adapt maternal …
Maternal obesity: new placental paradigms unfolded
C Brombach, W Tong, DA Giussani - Trends in molecular medicine, 2022 - cell.com
The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …
[HTML][HTML] Fish oil supplementation during pregnancy and postpartum in mothers with overweight and obesity to improve body composition and metabolic health during …
VV Satokar, JGB Derraik, M Harwood… - The American Journal of …, 2023 - Elsevier
Background Maternal obesity during pregnancy is associated with an increased risk of
obesity and metabolic disease in the offspring. Supplementation with fish oil (FO), which is …
obesity and metabolic disease in the offspring. Supplementation with fish oil (FO), which is …
Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice
OR Vaughan, FJ Rosario, J Chan… - The Journal of …, 2022 - Wiley Online Library
Obesity in pregnant women causes fetal cardiac dysfunction and increases offspring
cardiovascular disease risk, but its effect on myocardial metabolism is unknown. We …
cardiovascular disease risk, but its effect on myocardial metabolism is unknown. We …
[HTML][HTML] Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
AK Anam, KM Cooke, MB Dratver, JV O'Bryan… - Molecular …, 2022 - Elsevier
Objective Maternal obesity increases the incidence of excess adiposity in newborns,
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …
Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal …
SV Thangaraj, M Kachman, KM Halloran… - Science of the Total …, 2023 - Elsevier
Background Everyday, humans are exposed to a mixture of environmental chemicals some
of which have endocrine and/or metabolism disrupting actions which may contribute to non …
of which have endocrine and/or metabolism disrupting actions which may contribute to non …
Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity
Maternal immune activation is associated with adverse offspring neurodevelopmental
outcomes, many mediated by in utero microglial programming. As microglia remain …
outcomes, many mediated by in utero microglial programming. As microglia remain …
Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities
ED Santos, MH Hernández, V Sérazin… - International Journal of …, 2023 - mdpi.com
Maternal obesity is increasingly prevalent and is associated with elevated morbidity and
mortality rates in both mothers and children. At the interface between the mother and the …
mortality rates in both mothers and children. At the interface between the mother and the …
An integrated multi-OMICS approach highlights elevated non-esterified fatty acids impact BeWo trophoblast metabolism and lipid processing
Maternal obesity and gestational diabetes mellitus (GDM) are linked with impaired placental
function and early onset of non-communicable cardiometabolic diseases in offspring …
function and early onset of non-communicable cardiometabolic diseases in offspring …
The placenta's role in sexually dimorphic fetal growth strategies
JK Christians - Reproductive Sciences, 2022 - Springer
Fetal sex affects the risk of pregnancy complications and the long-term effects of prenatal
environment on health. Some have hypothesized that growth strategies differ between the …
environment on health. Some have hypothesized that growth strategies differ between the …