In the early 1920s, Warburg published experimental data on the enhanced conversion of
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …

Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Many tumors evolve sophisticated strategies to evade the immune system, and these
represent major obstacles for efficient antitumor immune responses. Here we explored a …

A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular
acidosis and intracellular alkalization. While consequences of extracellular acidosis are …

Acidosis, a common characteristic of the tumor microenvironment, is associated with
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …

Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …

Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer,
can lead to durable responses in the clinic, but response rates remain low due to undefined …

While cancer is commonly described as “a disease of the genes,” it is also associated with
massive metabolic reprogramming that is now accepted as a disease “Hallmark.” This …