Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator
retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has …

Diamond–Blackfan anemia (DBA) is a congenital bone marrow failure syndrome associated
with malformations. DBA is related to defective ribosome biogenesis, which impairs …

Production of red blood cells relies on proper mitochondrial function, both for their increased
energy demands during differentiation and for proper heme and iron homeostasis. Mutations …

In vitro surrogate models of human erythropoiesis made many contributions to our
understanding of the extrinsic and intrinsic regulation of this process in vivo and how they …

The rich history surrounding Diamond–Blackfan anaemia (DBA), originally described in
1938 as congenital hypoplastic anaemia2 reflects the evolution of paediatric haematology …

Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in
ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve …

In a recent issue of Blood, O'Brien et al1 describe the development of an ex vivo model of
Diamond-Blackfan anemia (DBA) using cultured peripheral blood CD34 1 progenitor cells …

Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes. Its
pathophysiology relies on a diversity of mechanisms supported by genetic events that …

Diamond-Blackfan anemia (DBA) is a rare genetic disorder in which patients present a
scarcity of erythroid precursors in an otherwise normocellular bone marrow. Most, but not all …

The emergence of multi-omic single-cell technologies over the last decade has led to
improved insights into both normal hematopoiesis and its perturbation in a variety of …