Reactive oxygen and reactive nitrogen species (ROS/RNS) have been implicated in the
pathogenesis of acute and chronic pancreatitis. Clinical and basic science studies have …

Secretagogues, such as cholecystokinin and acetylcholine, utilise a variety of second
messengers (inositol trisphosphate, cADPR and nicotinic acid adenine dinucleotide …

Oxidative stress may be an important determinant of the severity of acute pancreatitis. One-
electron reduction of oxidants generates reactive oxygen species (ROS) via redox cycling …

In severe acute pancreatitis, multiple organ failure in the early stage after onset, and sepsis
in the late stage, due to infection of pancreatic or peripancreatic devitalized tissue, contribute …

Disorders such as pancreatic or hepatic fibrosis are a cruel reminder that disruption of the
delicate physiological balance could result in severe pathological consequences. Fibrosis is …

The cellular events leading to pancreatitis have been studied extensively in experimental
models. Understanding the cellular events and inciting causes of the multisystem …

Acute pancreatitis (AP) remains a significant clinical challenge. Mitochondrial dysfunction
contributes significantly to the pathogenesis of AP. Milk fat globule EGF factor 8 (MFG‐E8) is …

Acute pancreatitis is a potentially lethal disorder characterized by inflammation and
apoptosis of parenchymal cells. Repeated acute pancreatitis results in chronic pancreatitis …

Severe acute pancreatitis (SAP) still remains a clinical challenge, not only for its high
mortality but the uncontrolled inflammatory progression from acute pancreatitis (AP) to SAP …

Abstract Background In China, Panax notoginseng has been used to treat oxidative stress-
related diseases for a long time. Panax notoginseng saponins is an extract from Panax …