Causes and mechanisms in acute pancreatitis

A Waldthaler, K Schütte, P Malfertheiner - Digestive Diseases, 2010 - karger.com
Acute pancreatitis (AP) presents clinically with either mild or severe clinical course. There
are no effective specific drugs for treatment of AP today. Basic knowledge about …

Transforming growth factor-β in pancreatic diseases: Mechanisms and therapeutic potential

Q Zhou, S Xia, F Guo, F Hu, Z Wang, Y Ni, T Wei… - Pharmacological …, 2019 - Elsevier
Pancreatic diseases, such as acute pancreatitis, chronic pancreatitis, and pancreatic cancer,
are common gastrointestinal diseases resulting in the development of local and systemic …

Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models

B Wei, Z Su, H Yang, Y Feng, C Meng, Z Liang - Biology Direct, 2023 - Springer
Objective Hypertriglyceridemia (HTG) is one of the common causes of acute pancreatitis
(AP). Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing …

Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein‐induced pancreatitis

M Eşrefoğlu, M Gül, B Ateş… - Journal of pineal …, 2006 - Wiley Online Library
The role of oxidative stress has been evaluated in experimental models of acute pancreatitis
(AP). The aim of this study is to investigate the effect of melatonin on the ultrastructural …

MANF protects pancreatic acinar cells against alcohol‐induced endoplasmic reticulum stress and cellular injury

H Wu, H Li, W Wen, Y Wang, H Xu, M Xu… - Journal of Hepato …, 2021 - Wiley Online Library
Abstract Background/Purpose Heavy alcohol drinking is associated with pancreatitis.
Pancreatitis is initiated by the damage to the pancreatic acinar cells. The endoplasmic …

[HTML][HTML] Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

XP Zhang, L Chen, QF Hu, H Tian, RJ Xu… - World Journal of …, 2007 - ncbi.nlm.nih.gov
AIM: To investigate the influence of high dose of dexamethasone on inflammatory mediators
and apoptosis of rats with severe acute pancreatitis (SAP). METHODS: SAP rats were …

[HTML][HTML] The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis …

B Nuche-Berenguer, I Ramos-Álvarez… - Biochimica et Biophysica …, 2016 - Elsevier
In a recent study we explored Group-1-p21-activated kinases (GP. 1-PAKs) in rat pancreatic
acini. Only PAK2 was present; it was activated by gastrointestinal-hormones …

Amelioration of experimental acute pancreatitis with Dachengqi Decoction via regulation of necrosis-apoptosis switch in the pancreatic acinar cell

J Wang, G Chen, H Gong, W Huang, D Long, W Tang - PLoS One, 2012 - journals.plos.org
Severity of acute pancreatitis contributes to the modality of cell death. Pervious studies have
demonstrated that the herb medicine formula “Dachengqi Decoction”(DCQD) could …

Saikosaponin d protects pancreatic acinar cells against cerulein‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway

H Chen, X Lu, B Xu, G Cheng, Y Li… - Journal of Applied …, 2024 - Wiley Online Library
Acute pancreatitis represents an inflammatory disease featuring pancreatic necrosis and
inflammation. Inflammatory injury of pancreatic acinar cells (PACs) is critically involved in the …

Melanoma: from incurable beast to a curable bet. The success of immunotherapy

ML Ascierto, I Melero, PA Ascierto - Frontiers in oncology, 2015 - frontiersin.org
After Coley's observation in 1891 of tumor regression in a patient who developed a
postoperative infection, the field of immunotherapy is finally reborn. Avoiding immune …