Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

The most severe form of malaria is caused by Plasmodium falciparum. These parasites
invade human erythrocytes, and an essential step in this process involves the ligand PfRh5 …

Nanoscale organization is crucial to stimulating an immune response. Using self-
assembling proteins as multimerization platforms provides a safe and immunogenic system …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and
cause malaria. Invasion requires multiple interactions between merozoite ligands and …

Erythrocyte invasion by Plasmodium falciparum merozoites is a highly intricate process in
which Plasmodium falciparum reticulocyte binding-like homologous protein 5 (PfRH5) is an …

Experimental studies of Plasmodium parasites that infect humans are restricted by their host
specificity. Humanized mice offer a means to overcome this and further provide the …

Peptide tags are a key resource, introducing minimal change while enabling a consistent
process to purify diverse proteins. However, peptide tags often provide minimal benefit post …

Understanding mechanisms of antibody synergy is important for vaccine design and
antibody cocktail development. Examples of synergy between antibodies are well …