Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Although inflammation has a physiological role, unrestrained inflammation can be
detrimental, causing tissue damage and disease. Under normal circumstances inflammation …

The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …

Purpose Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality.
We assessed the rate, diagnosis, and independent predictors for rehospitalisation in adult …

Sepsis is a global health priority, yet effective host‐directed targeted therapies have not
been identified outside of the setting of coronavirus disease 2019 (COVID‐19) …

Importance Sepsis survivors, defined as adult patients who survived to hospital discharge
following a critical care unit admission for sepsis, are at increased risk of long-term mortality …

Sepsis and cancer share a number of pathophysiological features, and both result from the
inability of the host's immune system to cope with the initial insult (tissue invasion by …

Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression,
and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical …