Embryonic diapause is an enigmatic state of dormancy that interrupts the normally tight
connection between developmental stages and time. This reproductive strategy and state of …

Diapause is a protective mechanism that many organisms deploy to overcome
environmental adversities. Diapause extends lifespan and fertility to enhance the …

Dynamic metabolism is exhibited by early mammalian embryos to support changing cell
fates during development. It is widely acknowledged that metabolic pathways not only satisfy …

Metabolism is crucial for development through supporting cell growth, energy production,
establishing cell identity, developmental signaling and pattern formation. In many model …

After fertilization, the zygote undergoes cell division. Up to the 8-cell stage, the blastomeres
of mouse preimplantation embryos are morphologically identical. The first cell differentiation …

Life on Earth has been through numerous challenges over eons and, one way or another,
has always triumphed. From mass extinctions to more daily plights to find food …

Embryonic diapause is a special reproductive phenomenon in mammals that helps embryos
to survive various harsh stresses. However, the mechanisms of embryonic diapause …

Embryonic diapause in mammals is a temporary developmental delay occurring at the
blastocyst stage. In contrast to other diapausing species displaying a full arrest, the …

Highlights•New data is providing insight into how embryonic diapause is
maintained.•FOXO1 and lipid metabolism have been identified as essential for …

Embryonic diapause in mammals describes a transient reduction of proliferation and
developmental progression occurring at the blastocyst stage. It was first described in the …