Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

Background A deep understanding of potential molecular biomarkers and therapeutic
targets related to the progression of colorectal cancer (CRC) from early stages to metastasis …

Colonic epithelial cells are responsible for maintaining a delicate balance between luminal
secretion and the absorption of fluids and ions. This review aims to discuss and update the …

Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by
various exchangers to transport other ions and organic substrates across cell membranes …

Background & Aims One of the features of ulcerative colitis (UC) is a defect in the protective
mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it …

Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …

Background & Aims The limited availability of organoid systems that mimic the molecular
signatures and architecture of human intestinal epithelium has been an impediment to …

Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing
intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea …

There is increasing evidence that the study of normal human enteroids duplicates many
known aspects of human intestinal physiology. However, this epithelial cell-only model lacks …