BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR)
genes lead to an increased risk of colorectal cancer (CRC), gynaecological cancers and …

Background A glioblastoma is a fatal type of brain tumour for which the standard of care is
maximum surgical resection followed by chemoradiotherapy, when possible. Age is an …

PURPOSE In the randomized open-label phase III OVHIPEC trial, the addition of
hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) …

Quality adjusted life years (QALYs) offer a measure of value which is advantageous for
health technology appraisal (HTA). As a composite measure, combining length of life and …

Background Several mapping algorithms have been published with the EORTC-QLQ-C30
for estimating EQ-5D-3L utilities. However, none are available with EQ-5D-5L. Moreover, a …

Background The types of outcomes measured collected in clinical studies and those
required for cost-effectiveness analysis often differ. Decision makers routinely use quality …

Background To develop direct and indirect (response) mapping algorithms from the
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire …

Purpose Patient-level utility data are needed for cost-utility analysis; in oncology, however,
the data are commonly gathered using disease-specific questionnaires that are often not …

Purpose It has been argued that generic health-related quality of life measures are not
sensitive to certain disease-specific improvements; condition-specific preference-based …

Background: Neuroendocrine tumours (NETs) are a group of heterogeneous cancers that
develop in cells in the diffuse neuroendocrine system. Objectives: To estimate the clinical …