Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

JG Beeson, DR Drew, MJ Boyle, G Feng… - FEMS microbiology …, 2016 - academic.oup.com
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

IA Cockburn, RA Seder - Nature immunology, 2018 - nature.com
Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
Malaria is a mosquito-borne disease caused by protozoan parasites of the genus
Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over …

Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease
transmitted by infected mosquitoes. Malaria remains a major global health challenge …

[HTML][HTML] Recent advances in recombinant protein-based malaria vaccines

SJ Draper, E Angov, T Horii, LH Miller, P Srinivasan… - Vaccine, 2015 - Elsevier
Plasmodium parasites are the causative agent of human malaria, and the development of a
highly effective vaccine against infection, disease and transmission remains a key priority. It …

The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
Malaria is a life‐threatening disease caused by parasites of the P lasmodium genus. In
many parts of the world, the parasites have developed resistance to a number of antimalarial …

Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de …

A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
Background BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based
on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to …

Controlled human malaria infection of healthy adults with lifelong malaria exposure to assess safety, immunogenicity, and efficacy of the asexual blood stage malaria …

JC Dejon-Agobe, U Ateba-Ngoa… - Clinical Infectious …, 2019 - academic.oup.com
Background GMZ2 is a recombinant malaria vaccine inducing immune responses against
Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We …