Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de …

A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
Background BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based
on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to …

Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies

M Chutiyami, P Saravanakumar, UM Bello, D Salihu… - Infection, 2024 - Springer
Aim The review summarizes the recent empirical evidence on the efficacy, safety, and
community perception of malaria vaccines in Africa. Methods Academic Search Complete …

Advancements and challenges in developing malaria vaccines: Targeting multiple stages of the parasite life cycle

Rajneesh, R Tiwari, VK Singh, A Kumar… - ACS Infectious …, 2023 - ACS Publications
Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …

Escaping the immune system: How the malaria parasite makes vaccine development a challenge

DI Stanisic, AE Barry, MF Good - Trends in parasitology, 2013 - cell.com
Malaria is a major cause of morbidity and mortality. Immunity is acquired but is suboptimal,
being slow to develop and incomplete. An inadequate understanding of natural immunity …

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children

EC Bougouma, NMQ Palacpac, AB Tiono… - Frontiers in …, 2022 - frontiersin.org
Background A blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite
Plasmodium falciparum could play a role to protect against clinical disease. Antibodies …

The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum

E Takashima, H Otsuki, M Morita, D Ito, H Nagaoka… - Biomolecules, 2024 - mdpi.com
Extensive control efforts have significantly reduced malaria cases and deaths over the past
two decades, but in recent years, coupled with the COVID-19 pandemic, success has …

Old and recent advances in life cycle, pathogenesis, diagnosis, prevention, and treatment of malaria including perspectives in Ethiopia

D Nureye, S Assefa - The Scientific World Journal, 2020 - Wiley Online Library
Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major
public health threat in many countries. This article aims to present different aspects of …

Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe children

AB Tiono, NMQ Palacpac, EC Bougouma… - Frontiers in …, 2023 - frontiersin.org
Background A vaccine targeting the erythrocyte stages of Plasmodium falciparum could play
a role in preventing clinical disease. BK-SE36 is a promising malaria vaccine candidate that …

New dimensions in the field of antimalarial research against malaria resurgence

AK Narula, CS Azad, LM Nainwal - European Journal of Medicinal …, 2019 - Elsevier
Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …

First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)

S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …