Antibody profiles to wheat germ cell-free system synthesized Plasmodium falciparum proteins correlate with protection from symptomatic malaria in Uganda
The key targets of protective antibodies against Plasmodium falciparum remain largely
unknown. In this study, we determined immunoreactivity to 1827 recombinant proteins …
unknown. In this study, we determined immunoreactivity to 1827 recombinant proteins …
Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines
DR Salamanca, M Gómez, A Camargo… - Frontiers in …, 2019 - frontiersin.org
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …
Low-Complexity Repetitive Epitopes of Plasmodium falciparum Are Decoys for Humoural Immune Responses
N Hou, N Jiang, Y Ma, Y Zou, X Piao, S Liu… - Frontiers in …, 2020 - frontiersin.org
Induction of humoural immunity is critical for clinical protection against malaria. More than
100 malaria vaccine candidates have been investigated at different developmental stages …
100 malaria vaccine candidates have been investigated at different developmental stages …
Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences
M Yagi, G Bang, T Tougan, NMQ Palacpac, N Arisue… - PLoS …, 2014 - journals.plos.org
The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of
Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we …
Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we …
Progress in the development of subunit vaccines against malaria
M Skwarczynski, S Chandrudu, B Rigau-Planella… - Vaccines, 2020 - mdpi.com
Malaria is a life-threatening disease and one of the main causes of morbidity and mortality in
the human population. The disease also results in a major socio-economic burden. The …
the human population. The disease also results in a major socio-economic burden. The …
[HTML][HTML] Malaria vaccines: facing unknowns
NMQ Palacpac, T Horii - F1000Research, 2020 - ncbi.nlm.nih.gov
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …
geographical spread and reducing malaria cases and deaths, can be attributed to large …
[HTML][HTML] Extended follow-up of children in a phase2b trial of the GMZ2 malaria vaccine
Background The GMZ2/alum candidate malaria vaccine had an efficacy of 14%(95%
confidence interval [CI]: 3.6%, 23%) against clinical malaria over 6 months of follow-up in a …
confidence interval [CI]: 3.6%, 23%) against clinical malaria over 6 months of follow-up in a …
Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population
Clinical immunity to malaria develops after repeated exposure to Plasmodium falciparum
parasites. Broadly reactive antibodies against parasite antigens expressed on the surface of …
parasites. Broadly reactive antibodies against parasite antigens expressed on the surface of …
Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery
TU Arumugam, D Ito, E Takashima… - Expert review of …, 2014 - Taylor & Francis
Malaria causes about 216 million clinical cases and 0.7 million deaths annually. One
promising route to address malaria is vaccination. However, so far, not even a single …
promising route to address malaria is vaccination. However, so far, not even a single …
Meeting report: WHO consultation on malaria vaccine development, Geneva, 15–16 July 2019
J Vekemans, D Schellenberg, S Benns, K O'Brien… - Vaccine, 2021 - Elsevier
Considerable progress has been made in malaria control in the last two decades, but
progress has stalled in the last few years. New tools are needed to achieve public health …
progress has stalled in the last few years. New tools are needed to achieve public health …