How can we develop an effective subunit vaccine to achieve successful malaria eradication?
S Pirahmadi, S Afzali, M Zargar, S Zakeri… - Microbial …, 2021 - Elsevier
Malaria, a mosquito-borne infection, is the most widespread parasitic disease. Despite
numerous efforts to eradicate malaria, this disease is still a health concern worldwide. Owing …
numerous efforts to eradicate malaria, this disease is still a health concern worldwide. Owing …
Identification of Plasmodium falciparum reticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine …
EH Ntege, N Arisue, D Ito, T Hasegawa, NMQ Palacpac… - Vaccine, 2016 - Elsevier
Genetic variability in Plasmodium falciparum malaria parasites hampers current malaria
vaccine development efforts. Here, we hypothesize that to address the impact of genetic …
vaccine development efforts. Here, we hypothesize that to address the impact of genetic …
Vaccines to accelerate malaria elimination and eventual eradication
J Healer, AF Cowman… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Remarkable progress has been made in coordinated malaria control efforts with substantial
reductions in malaria-associated deaths and morbidity achieved through mass …
reductions in malaria-associated deaths and morbidity achieved through mass …
Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5
T Tougan, JR Edula, E Takashima, M Morita… - Scientific reports, 2018 - nature.com
The malaria parasite Plasmodium falciparum proliferates in the blood stream where the host
immune system is most active. To escape from host immunity, P. falciparum has developed a …
immune system is most active. To escape from host immunity, P. falciparum has developed a …
Characteristic features of the SERA multigene family in the malaria parasite
N Arisue, NMQ Palacpac, T Tougan, T Horii - Parasites & vectors, 2020 - Springer
Serine repeat antigen (SERA) is conserved among species of the genus Plasmodium. Sera
genes form a multigene family and are generally tandemly clustered on a single …
genes form a multigene family and are generally tandemly clustered on a single …
Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism
NMQ Palacpac, KJ Ishii, N Arisue, T Tougan… - Parasitology …, 2023 - Elsevier
The call for second generation malaria vaccines needs not only the identification of novel
candidate antigens or adjuvants but also a better understanding of immune responses and …
candidate antigens or adjuvants but also a better understanding of immune responses and …
The search of a malaria vaccine: the time for modified immuno-potentiating probes
JM Lozano, Z Rodríguez Parra, S Hernández-Martínez… - Vaccines, 2021 - mdpi.com
Malaria is a deadly disease that takes the lives of more than 420,000 people a year and is
responsible for more than 229 million clinical cases globally. In 2019, 95% of malaria …
responsible for more than 229 million clinical cases globally. In 2019, 95% of malaria …
Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates
EH Ntege, E Takashima, M Morita… - Expert Review of …, 2017 - Taylor & Francis
Introduction: An efficacious malaria vaccine is necessary to advance the current control
measures towards malaria elimination. To-date, only RTS, S/AS01, a leading pre …
measures towards malaria elimination. To-date, only RTS, S/AS01, a leading pre …
Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)
A Somanathan, SY Mian, K Chaddha, S Uchoi… - Frontiers in …, 2022 - frontiersin.org
Plasmodium falciparum Cysteine-Rich Protective Antigen (CyRPA) is an essential, highly
conserved merozoite antigen that forms an important multi-protein complex …
conserved merozoite antigen that forms an important multi-protein complex …
Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA
P Favuzza, S Blaser, AM Dreyer, G Riccio… - Malaria journal, 2016 - Springer
Background The pathogenesis of malaria is primarily associated with blood-stage infection
and there is strong evidence that antibodies specific for parasite blood-stage antigens can …
and there is strong evidence that antibodies specific for parasite blood-stage antigens can …