Malaria vaccines: facing unknowns

H Toshihiro - F1000Research, 2020 - search.proquest.com
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …

Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5): current vaccine candidate for Plasmodium falciparum malaria

A Bulaan, WRW Mulyani, AN Mahendra… - Intisari Sains …, 2020 - isainsmedis.id
Background:  Most of the malaria cases are caused by Plasmodium falciparum infection.
The prevalence of cases and high mortality rates due to malaria should be watched out …

[PDF][PDF] Malaria vaccines: facing unknowns [version 1; peer review: 2

NMQ Palacpac, T Horii - 2020 - pdfs.semanticscholar.org
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …

[图书][B] The Role of Complement in Antibody-Dependent Acquired Immunity to Plasmodium falciparum Malaria

PK Kiyuka - 2020 - search.proquest.com
Many pathogens evade complement recognition by binding to complement regulatory
proteins, such as factor H (FH), that protect host cells from complement attack. Asexual …

Infectious plasmodium sporozoites grown in vitro

AG Eappen, SL Hoffman - US Patent 11,207,395, 2021 - Google Patents
The application is directed to in vitro-reared Plasmodium sporozoites of human host range
wherein sporogony from gametocyte stage to sporozoite stage is external to mosqui toes …

Novel empirical and bioinformatic approaches to characterising Plasmodium falciparum antigens and their application to a merozoite-stage vaccine candidate

HMJ Aspeling-Jones - 2019 - researchonline.lshtm.ac.uk
A highly efficacious vaccine against the malaria parasite Plasmodium falciparum is needed.
Repeat sequences are common in P. falciparum proteins and some are known immune …

Identification and assessment of antigens involved in membrane traversal by malaria parasites as vaccine candidates

F Brod - 2018 - ora.ox.ac.uk
Malaria is a mosquito borne disease caused by parasites of the genus Plasmodium,
inflicting a high number of infections and deaths each year. Since the end of the last century …

[HTML][HTML] Safety, immunogenicity, and cross-species protection of a plasmid DNA encoding Plasmodium falciparum SERA5 polypeptide, microbial epitopes and …

N Onkoba, RM Mumo, H Ochanda… - Journal of Biomedical …, 2017 - ncbi.nlm.nih.gov
Incorporation of biomolecular epitopes to malarial antigens should be explored in the
development of strain-transcending malarial vaccines. The present study sought to …

Subunit Blood-Stage Malaria Vaccines

AD Douglas - Malaria: Immune Response to Infection and …, 2017 - Springer
The existence of asymptomatically parasitemic individuals in malaria-endemic areas has
long been recognised to signify naturally acquired immunity to malaria disease, resulting …

Prospects for enhancing malaria vaccine efficacy by combining pre-erythrocytic antigens

E Atcheson - 2017 - ora.ox.ac.uk
Malaria causes almost half a million deaths each year. Existing interventions will almost
certainly not be enough to tackle this enormous public health problem on their own. An …