One of the major challenges the scientific community faces today is the lack of translational
data generated from mouse trials for human health application. Housing temperature …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …

Objective To investigate the abundance and the prevalence of Dysosmobacter welbionis
J115T, a novel butyrate-producing bacterium isolated from the human gut both in the …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Brown/beige adipocytes are therapeutic targets to combat obesity due to their abilities to
dissipate energy through adaptive thermogenesis. Most studies investigating induction of …

Mammals regulate fat mass so that increases or reductions in adipose tissue mass activate
responses that favor return to one's previous weight. A reduction in fat mass activates a …

The 'mild'cold stress caused by standard sub-thermoneutral housing temperatures used for
laboratory mice in research institutes is sufficient to significantly bias conclusions drawn from …

Background A chronic imbalance of energy intake and energy expenditure results in excess
fat storage. The obesity often caused by this overweight is detrimental to the health of …

Brown adipose tissue (BAT) contributes to whole body energy expenditure (EE), especially
cold-induced thermogenesis (CIT), in humans. Although it is known that EE and CIT vary …