The frequently studied polysaccharide, chitosan oligosaccharide/chitooligosaccharide
(COS) is the major degradation product of chitosan/chitin via chemical hydrolysis or …

Chitosan oligosaccharide (COS) is an oligomer of β-(1➔ 4)-linked d-glucosamine. COS can
be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

The cholinergic system in the brain plays crucial roles in regulating sensory and motor
functions as well as cognitive behaviors by modulating neuronal activity. Understanding the …

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence
of AD rises in the 21st century, there is an urgent need for the development of effective …

Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

In this comprehensive review, we examine the main preclinical and clinical investigations
assessing the effects of different forms of choline supplementation currently available …

Recent studies have suggested the role of an infectious component in the pathogenesis of
Alzheimer's disease (AD). In light of this, research has focused on some bacteria constituting …