Acute inflammatory responses are one of the major underlying mechanisms for tissue
damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung …

Vascular endothelial cadherin (VE-cadherin) is an endothelial-specific, trans-membrane
protein that promotes homophilic cell adhesion. Inhibition of VE-cadherin by the blocking …

The presence of Porphyromonas gingivalis in the periodontal pocket and the high levels of
gingipain activity detected in gingival crevicular fluid could implicate a role for gingipains in …

Chronic stress may precipitate psychiatric disorders including anxiety. We reported that
Repeated Social Defeat (RSD) in mice increased accumulation of inflammatory monocytes …

Angiogenesis, the formation of new blood vessels, is essential for tumor growth, progression
and metastasis. The development of agents that target tumor vasculature is ultimately …

Tyrosine kinase inhibitors (TKIs) are the most commonly used targeted therapeutics in clear-
cell renal cell carcinoma (ccRCC); however, drug resistance limits their utility and can lead …

The invasive properties of cancer cells depend on their intrinsic motile potential and on their
ability to breach the endothelial barrier. In the present work, we investigated the …

Thrombospondin-1 (TSP1) can inhibit angiogenesis by interacting with endothelial cell
CD36 or proteoglycan receptors. We have now identified α3β1 integrin as an additional …

The maintenance of endothelial cell (EC) monolayer architecture requires stable adhesions
not only between neighboring cells but also between cells and the extracellular matrix …

Adherens junctions and more specifically cadherins play an important role in endothelial cell
integrity and growth and, in general, in vascular morphogenesis. Besides their adhesive …