During Drosophila melanogaster heart development, a lumen forms between apical
surfaces of contralateral cardioblasts (CBs). We show that Slit and its receptor Roundabout …

The pulmonary endothelial cell forms a critical semi-permeable barrier between the vascular
and interstitial space. As part of the blood-gas barrier in the lung, the endothelium plays a …

During embryogenesis, the primordial microcirculation is formed through a process known
as vasculogenesis. The term “vasculogenic mimicry” has been used to describe the manner …

Endothelial cells are known to respond to mechanical forces such as fluid shear stress and
cyclic stretch, but elucidating the mechanism for mechanosensing has been difficult …

We previously reported that vascular endothelial growth factor (VEGF) increases vascular
permeability through the synthesis of endothelial platelet‐activating factor (PAF), while …

Документ создан при поддержке Национальной медицинской Ассоциации по изучению
Сочетанных Заболеваний (НАСЗ). В 2021 г. опубликован первый национальный …

RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation.
Whereas the relevance of RhoA for endothelial barrier function is widely accepted, the role …

HIV-1 infection leads to the development of HIV-associated neurological disorders. The HIV-
1 Tat protein has been reported to exert an adverse effect on blood–brain barrier integrity …

Aims Endothelial barrier dysfunction is a key event in the pathogenesis of vascular diseases
associated with inflammation. ADAM (a disintegrin and metalloprotease) 15 has been …

Src family kinases (SFKs) are signaling enzymes that have long been recognized to regulate
critical cellular processes such as proliferation, survival, migration, and metastasis. Recently …