The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …

Contrary to classic theory prediction, sex-chromosome homomorphy is prevalent in the
animal kingdom but it is unclear how ancient homomorphic sex chromosomes avoid …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Donafenib is a
multi‐receptor tyrosine kinase inhibitor approved for the treatment of patients with advanced …

Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Sea urchins are emblematic models in developmental biology and display several
characteristics that set them apart from other deuterostomes. To uncover the genomic cues …

Unstable transcripts have emerged as markers of active enhancers in vertebrates and
shown to be involved in many cellular processes and medical disorders. However, their …