Developing biocompatible, synthetic oxygen carriers is a consistently challenging task that
researchers have been pursuing for decades. Perfluorocarbons (PFC) are fascinating …

The pursuit for blood a substitute has spanned over a century, but a majority of the efforts
have been disappointing. As of today, there is no widely accepted product used as an …

Hemoglobin vesicles (Hb-V) are artificial red blood cells encapsulating highly concentrated
hemoglobin (Hb) in liposomes comprising phospholipids, cholesterol, negatively charged …

First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for
use as a transfusion alternative | Blood Advances | American Society of Hematology Skip to …

Background Several circumstances such as accidents, surgery, traumatic hemorrhagic
shock, and other causalities cause major blood loss. Allogenic blood transfusion can be …

Oxygen (O2) is indispensable for aerobic respiration and cellular metabolism. In case of
injury, reactive oxygen species are produced, causing oxidative stress, which triggers cell …

Transfusion support and alternatives for Jehovah's Witness p... : Current Opinion in Hematology
Transfusion support and alternatives for Jehovah's Witness patients : Current Opinion in …

Timely administration of donor red blood cells (RBCs) is a crucial and life-saving procedure
to restore tissue oxygenation in patients suffering from acute blood loss. However, important …

This paper describes the synthesis and O2 binding properties of core–shell structured
hemoglobin (Hb) nanoparticles (NPs), artificial O2 carriers of five types, as designed for use …

The use of blood for normothermic and subnormothermic kidney preservation hinders the
translation of these approaches and promising therapeutics. This study evaluates whether …