Perflurocarbon-based oxygen carriers (PBOC) represent a major category of artificial
oxygen therapeutics. Since their initial report of potential oxygen-carrying capability half a …

There has been a global shortage of allogeneic human blood, and human blood transfusion
has been associated with many side effects and complications. Thus, the pursuit for …

Introduction To assist design of future HBOC clinical trials for pre-hospital and prolonged
field care, the haemoglobin-based-oxygen carrier (HBOC) Phase III trauma trial database …

Abstract Purpose of Review This manuscript aims to review the current state of perioperative
blood management as well as prognosticate future directions for the field. Recent Findings …

Background Hemorrhagic shock is a clinically challenging disease process with high
mortality. When conventional blood products are unable to be administered, oxygen …

Background: Hemoglobin-based oxygen carriers (HBOCs) may cause coagulopathy,
changes in total hemoglobin (THb), and affect mortality. Low total hemoglobin …

JS Jahr: Hemosol Incorporated: principal investigator in 2 phase II/III trials (1999–2002);
Biopure Corporation: principal investigator in 2 phase II/III trials (1996–2001); and Alliance …

Hemorrhagic shock is a major source of morbidity and mortality worldwide. While whole
blood or blood product transfusion is a first line treatment, maintaining robust supplies …

Sanguinate is a unique polyethylene glycol modified form of bovine hemoglobin that
represents the latest generation of hemoglobin-based oxygen carriers. Its structural …

Separate topics discuss specific strategies for blood management during cardiac surgery
with cardiopulmonary bypass (CPB).(See" Blood management and anticoagulation for …