This article reviews parameters of extrinsic uncoupling of oxidative phosphorylation
(OxPhos) in mitochondria, based on induction of a proton leak across the inner membrane …

In the past few years it has become apparent that mitochondria have an essential role in the
life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic …

Chronic systemic complex I inhibition caused by rotenone exposure induces features of
Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic …

Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and
hydrogen peroxide, act as necessary signaling molecules in processes underlying …

Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT
and NT) and are linked to the increase in incidence of autism, attention deficit and …

Objective To determine whether chronic treatment with celecoxib, a cyclooxygenase‐2
inhibitor that has been shown to be beneficial in preclinical testing, is safe and effective in …

The pathogenesis of cell death in amyotrophic lateral sclerosis (ALS) may involve glutamate‐
mediated excitotoxicity, oxidative damage, and apoptosis. We used a transgenic mouse …

The results of many investigations have shown that calcium is essential for production of
reactive oxygen species (ROS). Elevation of intracellular calcium level is responsible for …

Phosphorylation of isolated cytochrome c oxidase from bovine kidney and heart, and of the
reconstituted heart enzyme, with protein kinase A, cAMP and ATP turns on the allosteric ATP …

Turmeric is a source of numerous aromatic compounds isolated from powdered rhizomes of
Curcuma longa Linn. The constituents are present as volatile oil, the Curcuma oil (C. oil) …