Insulin resistance is strongly associated with metabolic dyslipidemia, which is largely a
postprandial phenomenon. Though previously regarded as a consequence of delayed …

Protein transport in the secretory and endocytic pathways is a multistep process involving
the generation of transport carriers loaded with defined sets of cargo, the shipment of the …

Methyl mercury (MeHg) is a neurotoxicant with adverse effects on the development of the
nervous system from fish to man. Despite a detailed understanding of the molecular …

The transport of proteins and lipids between the endoplasmic reticulum and Golgi apparatus
is initiated by the collection of secretory cargo from within the lumen of the endoplasmic …

The majority of biosynthetic secretory proteins initiate their journey through the
endomembrane system from specific subdomains of the endoplasmic reticulum. At these …

Congenital dyserythropoietic anemias belong to a group of inherited conditions
characterized by a maturation arrest during erythropoiesis with a reduced reticulocyte …

Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates
with the endoplasmic reticulum (ER) membrane and recruits COPII components …

The study of apolipoprotein (apo) B metabolism is central to our understanding of human
lipoprotein metabolism. Moreover, the assembly and secretion of apoB-containing …

Abstract Microvillous Inclusion Disease (MID) is a rare, autosomal recessive gastrointestinal
disease of increased frequency among the Navajos. Previous work has shown a deficiency …

Cargo proteins exiting the endoplasmic reticulum en route to the Golgi are typically carried
in 60–70nm vesicles surrounded by the COPII protein coat. Some secretory cargo …