Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Background Alzheimer's disease is characterized by the presence of cortical amyloid-beta
(Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase …

Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch
homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL). However, limited …

A rapid increase in incidence of neurodegenerative disorders has been observed with the
aging of the population. Alzheimer's disease (AD) is the most common neurodegenerative …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of
amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting
from the malignant transformation of immature T-cell progenitors. Originally associated with …

Abstract Glycogen synthase kinase 3 (GSK‐3) dysregulation is implicated in the two
Alzheimer's disease (AD) pathological hallmarks: β‐amyloid plaques and neurofibrillary …

Curcumin, the phytochemical agent in the spice turmeric, which gives Indian curry its yellow
colour, is also a traditional Indian medicine. It has been used for millennia as a wound …