Autophagy inhibitors for cancer therapy: small molecules and nanomedicines

JL Chen, X Wu, D Yin, XH Jia, X Chen, ZY Gu… - Pharmacology & …, 2023 - Elsevier
Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

J Zhang, Z Chen, D Shan, Y Wu, Y Zhao, C Li… - Journal of …, 2024 - Elsevier
Particulate pollution is a global risk factor that seriously threatens human health. Fine
particles (FPs) and ultrafine particles (UFPs) have small particle diameters and large specific …

Incomplete autophagy: Trouble is a friend

Q Zhang, S Cao, F Qiu, N Kang - Medicinal Research Reviews, 2022 - Wiley Online Library
Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …

[HTML][HTML] Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH …

F Xiaoli, Z Yaqing, L Ruhui, L Xuan, C Aijie… - Journal of hazardous …, 2021 - Elsevier
Graphene oxide (GO) nanomaterials have significant advantages for drug delivery and
electrode materials in neural science, however, their exposure risks to the central nervous …

The Role and Potential Regulatory Mechanism of STING Modulated Macrophage Apoptosis and Differentiation in Severe Acute Pancreatitis-Associated Lung Injury

Y Peng, Y Li, Y Yang, T Shi, R Liu, Y Luan… - Journal of Interferon & …, 2023 - liebertpub.com
This study aims to investigate the role of STING in promoting macrophage apoptosis and
regulating macrophage polarization in severe acute pancreatitis (SAP)-associated lung …

[HTML][HTML] The HL-60 human promyelocytic cell line constitutes an effective in vitro model for evaluating toxicity, oxidative stress and necrosis/apoptosis after exposure to …

RAS Benavides, JM Leiro-Vidal… - Science of the Total …, 2023 - Elsevier
The cellular and molecular mechanisms by which atmospheric pollution from particulate
matter and/or electromagnetic fields (EMFs) may prove harmful to human health have not …

Mitochondrial oxidative stress is the general reason for apoptosis induced by different-valence heavy metals in cells and mitochondria

SM Korotkov - International Journal of Molecular Sciences, 2023 - mdpi.com
This review analyzes the causes and consequences of apoptosis resulting from oxidative
stress that occurs in mitochondria and cells exposed to the toxic effects of different-valence …

The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to …

LC Costa-Beber, FTCR Guma - Inflammation Research, 2022 - Springer
Introduction Cardiovascular diseases (CVD) have been associated with high exposure to
fine particulate air pollutants (PM2. 5). Alveolar macrophages are the first defense against …

Exploration of potential mechanism of interleukin-33 up-regulation caused by 1, 4-naphthoquinone black carbon in RAW264. 7 cells

Z Li, W Jiang, H Chu, J Ge, X Wang, J Jiang… - Science of The Total …, 2022 - Elsevier
Background As air pollution has been paid more attention to by public in recent years,
effects and mechanism in particulate matter-triggered health problems become a focus of …

Sodium para-aminosalicylic acid modulates autophagy to lessen lead-induced neurodegeneration in rat cortex

L Wang, X Zhu, Y Fang, Y Li, Y Zhao, C Gan, J Luo… - Neurotoxicity …, 2023 - Springer
Lead (Pb) is a common heavy metal contaminant in the environment, and it may perturb
autophagy and cause neurodegeneration. Although sodium para-aminosalicylic (PAS-Na) …