The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI
C Liu, H Sun, Y Yi, W Shen, K Li, Y Xiao, F Li, Y Li… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease
Abstract Background N6-methyladenosine (m 6 A) modification is known to impact many
aspects of RNA metabolism, including mRNA stability and translation, and is highly …
aspects of RNA metabolism, including mRNA stability and translation, and is highly …
Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
P Bawankar, T Lence, C Paolantoni… - Nature …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification on mRNA
which influences most steps of mRNA metabolism and is involved in several biological …
which influences most steps of mRNA metabolism and is involved in several biological …
Genetic drivers of m6A methylation in human brain, lung, heart and muscle
The most prevalent post-transcriptional mRNA modification, N 6-methyladenosine (m6A),
plays diverse RNA-regulatory roles, but its genetic control in human tissues remains …
plays diverse RNA-regulatory roles, but its genetic control in human tissues remains …
The role of N6-methyladenosine mRNA in the tumor microenvironment
M Li, X Zha, S Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
In recent years, the most widely distributed eukaryotic messenger RNA (mRNA)
modification, N6-methyladenosine (m6A), has received a large amount of interest, in part …
modification, N6-methyladenosine (m6A), has received a large amount of interest, in part …
Altered expression of the m6A methyltransferase METTL3 in Alzheimer's disease
H Huang, J Camats-Perna, R Medeiros, V Anggono… - Eneuro, 2020 - eneuro.org
Cognitive impairment in Alzheimer's disease (AD) is associated with dysregulation of the
RNA and protein expression profiles in the brain. Recent studies have highlighted the …
RNA and protein expression profiles in the brain. Recent studies have highlighted the …
N6-methyladenosine and neurological diseases
N Zhang, C Ding, Y Zuo, Y Peng, L Zuo - Molecular neurobiology, 2022 - Springer
Abstract N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the
adenosine N6 position and is the most common chemical epigenetic modification among …
adenosine N6 position and is the most common chemical epigenetic modification among …