Identification of 18β-glycyrrhetinic acid as an AGT inhibitor against LPS-induced myocardial dysfunction via high throughput screening

M Shi, S Zhang, J Rong, Z Heng, Y Xu, Y Wang… - Biochemical …, 2024 - Elsevier
Sepsis induced myocardial dysfunction (SIMD) is a serious complication of sepsis. There is
increasing evidence that the renin-angiotensin system (RAS) is activated in SIMD …

Zilebesiran—the first siRNA-based drug in hypertensiology: why is it needed, and will it change the treatment approach of hypertension?

S Surma, S Oparil - Arterial Hypertension, 2024 - journals.viamedica.pl
Arterial hypertension is the most common cardiovascular risk factor in the world. The
prevalence of hypertension has doubled over the last 30 years. Despite the availability of …

Inhalable Therapies for the Heart: Take the “Lung” Way Home?

JS Hulot, C Kupatt - Journal of the American College of Cardiology, 2024 - jacc.org
Molecular therapies have the potential to revolutionize the way we are managing patients
with cardiovascular diseases. Many targets are involved in abnormal ion balances, deficient …

Zilebesiran--pierwszy lek oparty na technologii siRNA w terapii nadciśnienia tętniczego.

S Surma, K Narkiewicz - Heart & Vascular Diseases …, 2023 - search.ebscohost.com
Nadciśnienie tętnicze jest najczęstszym czynnikiem ryzyka chorób układu sercowo-
naczyniowego (CVD) na świecie. W ostatnich 30 latach częstość występowania …

Preliminary Study on Total Glucoside of Peony (TGP) Administration in Organ-Specific Autoimmune Diseases at Prof. dr. RD Kandou Hospital, Indonesia

NC Mongdong, EA Datau, EE Surachmanto… - Asian Journal of …, 2024 - ajesh.ph
Autoimmune diseases are a diverse group of conditions characterized by immune
disturbances that cause aberrant B cell and T cell reactivity to normal constituents of the …

The Effect Of Injecting siRNA Angiotensinogen On Wistar Strain Male Rats (Rattus Norvegicus) Blood Pressure

J Rusli - Asian Journal of Engineering, Social and Health, 2024 - ajesh.ph
High blood pressure, or hypertension, is a major risk factor for various cardiovascular
diseases and chronic heart failure. Although medication can help lower blood pressure, it …